Nucleic acid detection is increasingly required by people, and one of its key steps is to extract nucleic acid. Nickel plating on the surface of hollow glass microspheres can make it have good corrosion resistance and magnetism. Due to the small size of the microspheres, the method of electroplating nickel is not feasible, so the method of electroless nickel plating is needed to plate nickel on the surface of the microspheres. The presence of phosphorus in the electroless nickel layer will make the coating become paramagnetic, so it needs to be annealed to change the structure of the coating to make it ferromagnetic. Plating silica or other surface modification on the magnetic microspheres can make the magnetic microspheres able to adsorb specific nucleic acids. The magnetic properties of the microspheres are stronger and easier to control. When they are in an aqueous solution, microspheres of different densities can automatically layer in the solution to better achieve the effect of adsorbing nucleic acids. The larger volume allows the microspheres to be adsorbed by the magnet faster, which speeds up the nucleic acid extraction efficiency and simplifies the nucleic acid detection steps.

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